Enter the zombie apocalyptic world where almost every human is infected by the Green Flu. Four survivors – Coach, Ellis, Nick and Rochelle are now fighting their way to reach the US safe zone but surviving thousands of zombies along the way isn't easy. The 4 companions must battle through 5 campaigns and travel across Savannah, Georgia and New Orleans fighting hordes of zombies along the way. New monsters include 3 new "Special Infected" zombies such as The Charger who has an enormous right arm and uses it to pummel players into the ground. Gunfire and slashing is also more realistic, as players see bullets and melee weapons tear off the flesh and limbs of zombies.

Relying on shotguns, assault rifles, chainsaws and their instincts, the four will travel a terrifying path while recalling their back-stories on the way. Will they survive the zombies?